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HCV CoreProtein (107-114) is a least immunogenic residue of the major linear HCVcore regions. HCV CoreProtein (107-114) is identified as the binding site within the region 101-118, which contains two residues differing between genotypes Ⅰ/Ⅱ and Ⅲ/Ⅵ. HCV CoreProtein (107-114) might be a potential site for dissemination of HCV serotypes .
AB-506 is an orally active inhibitor of HBV replication targeting the viral coreprotein. AB-506 can bind to HBV coreprotein, accelerate capsid assembly and inhibit HBV pgRNA encapsidation. AB-506 can be used in chronic hepatitis B (CHB) research .
BA-53038B is a HBV coreprotein allosteric modulator (CpAM), binding to the HAP pocket and modulating HBV capsid assembly. BA-53038B has antiviral activity for hepatitis B virus (HBV) with an EC50 value of 3.32 μM. BA-53038B can be used for the research of chronic hepatitis B .
MUC1, mucin core is the region of the MUC1 mucin core. MUC1 is a type I transmembrane glycoprotein, and is overexpressed and aberrantly glycosylated in carcinoma cells. MUC1, mucin coreprotein binds to domain 1 of ICAM-1 .
TPCK (L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK) is a potent serine protease inhibitor that reacts with the retinoblastoma protein (RB)-binding core of HPV-18 E7 protein and abolish its RB-binding capability. TPCK is able to modify E7 protein in live keratinocytes following its addition to the culture medium .
PIP-199 is a selective inhibitor of RMI (RecQ-mediated genome instability protein) core complex/MM2 interaction, with an IC50 of 36 μM. PIP-199 can be used for the research of sensitizing resistant tumors to DNA crosslinking chemotherapeutics .
Nosiheptide (Multhiomycin), a thiopeptide antibiotic produced by Streptomyces actuosus, inhibits bacterialprotein synthesis and bears a unique indole side ring system and regiospecific hydroxyl groups on the characteristic macrocyclic core. Nosiheptide has been widely used as a feed additive for animal growth .
β-Amyloid (12-28) (Amyloid β-Protein (12-28)) is a peptide fragment of β-amyloid protein (β1-42). β1-42, a 42 amino acid protein , is the major component of senile plaque cores. β-Amyloid (12-28) shows aggregation properties. β-Amyloid (12-28) has the potential for Alzheimer’s disease research .
Chondroitinase ABC (ChABC) is an enzyme that degrades glycosaminoglycan side-chains of chondroitin sulfate (CS-GAG) from the chondroitin sulfate proteoglycan (CSPG) coreprotein. Chondroitinase ABC facilitates reinnervation by degrading CS-GAGs around motoneurons. Chondroitinase ABC has the potential for the research of spinal injury .
β-Amyloid (12-28) (TFA) (Amyloid β-Protein (12-28) (TFA)) is a peptide fragment of β-amyloid protein (β1-42). β1-42, a 42 amino acid protein , is the major component of senile plaque cores. β-Amyloid (12-28) (TFA) shows aggregation properties. β-Amyloid (12-28) (TFA) has the potential for Alzheimer’s disease research .
Vebicorvir (ABI-H0731) is a first-generation hepatitis B virus (HBV) coreprotein inhibitor. Vebicorvir (ABI-H0731) suppresses covalently closed circular DNA (cccDNA) formation in two de novo infection models with EC50s from 1.84 μM to 7.3 μM .
HCV Peptide (35-44), a HCV coreprotein at positions 35 to 44, is a HLA-A2-restricted CTL epitope. HCV Peptide (35-44) inhibits NK cell activity via two distinct mechanisms, directly via KIR2DL2/3, and synergistically via the CD94:NKG2A receptor .
MUC1, mucin core is the region of the MUC1 mucin core. MUC1 is a type I transmembrane glycoprotein, and is overexpressed and aberrantly glycosylated in carcinoma cells. MUC1, mucin coreprotein binds to domain 1 of ICAM-1 .
HCV CoreProtein (107-114) is a least immunogenic residue of the major linear HCVcore regions. HCV CoreProtein (107-114) is identified as the binding site within the region 101-118, which contains two residues differing between genotypes Ⅰ/Ⅱ and Ⅲ/Ⅵ. HCV CoreProtein (107-114) might be a potential site for dissemination of HCV serotypes .
β-Amyloid (12-28) (Amyloid β-Protein (12-28)) is a peptide fragment of β-amyloid protein (β1-42). β1-42, a 42 amino acid protein , is the major component of senile plaque cores. β-Amyloid (12-28) shows aggregation properties. β-Amyloid (12-28) has the potential for Alzheimer’s disease research .
β-Amyloid (12-28) (TFA) (Amyloid β-Protein (12-28) (TFA)) is a peptide fragment of β-amyloid protein (β1-42). β1-42, a 42 amino acid protein , is the major component of senile plaque cores. β-Amyloid (12-28) (TFA) shows aggregation properties. β-Amyloid (12-28) (TFA) has the potential for Alzheimer’s disease research .
HCV Peptide (35-44), a HCV coreprotein at positions 35 to 44, is a HLA-A2-restricted CTL epitope. HCV Peptide (35-44) inhibits NK cell activity via two distinct mechanisms, directly via KIR2DL2/3, and synergistically via the CD94:NKG2A receptor .
Amyloid β-Protein (3-42) is the precursor of Pyr peptide. Pyroglutamate-modified Aβ (pEAβ) (3-42) is the core of the amyloid template block in Alzheimer's disease. pEAβ(3-42) accelerated the aggregation of Aβ(1-42), while Aβ(1-42) significantly slowed the primary and secondary nucleation of pEAβ(3-42) .
Nosiheptide (Multhiomycin), a thiopeptide antibiotic produced by Streptomyces actuosus, inhibits bacterialprotein synthesis and bears a unique indole side ring system and regiospecific hydroxyl groups on the characteristic macrocyclic core. Nosiheptide has been widely used as a feed additive for animal growth .
Serine (SRGN) is essential for the formation of mast cell secretory granules and the storage of various compounds. It plays a crucial role in the storage of proteases in mast cells, including granzyme B in T lymphocytes, and contributes to the localization of neutrophil elastase. Serglycin/SRGN Protein, Human (HEK293, His-Myc) is the recombinant human-derived Serglycin/SRGN protein, expressed by HEK293 , with C-His, C-Myc labeled tag. The total length of Serglycin/SRGN Protein, Human (HEK293, His-Myc) is 158 a.a., with molecular weight of ~27 kDa.
Capsid proteins play a key role in the assembly of icosahedral capsids, forming T=4 and T=3 particles. Transported along microtubules to the nucleus, its phosphorylation exposes a nuclear localization signal that promotes binding to nuclear pore complexes via α and β import. Capsid protein, Hepatitis B Virus (His) is the recombinant Virus-derived Capsid protein, expressed by E. coli , with C-His labeled tag. The total length of Capsid protein, Hepatitis B Virus (His) is 149 a.a., with molecular weight of ~17.67 kDa.
BCAN Protein, Human (HEK293, His) is a recombinant human brevican core protein produced in HEK293 cells. In the adult brain, the brevican core protein undergoes proteolytic cleavage and exists as a 145-kDa full-length form and an 80-kDa C-terminal fragment.
SDC4 protein is a cell surface proteoglycan that cooperates with SDCBP and PDCD6IP to regulate exosome biogenesis. SDC4 exists as a homodimer and engages in important interactions with various intracellular partners. SDC4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived SDC4 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of SDC4 Protein, Mouse (HEK293, His) is 122 a.a., with molecular weight of ~22.21 kDa.
SDC4 protein is a cell surface proteoglycan that cooperates with SDCBP and PDCD6IP to regulate exosome biogenesis. SDC4 exists as a homodimer and engages in important interactions with various intracellular partners. SDC4 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived SDC4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of SDC4 Protein, Mouse (HEK293, Fc) is 123 a.a., with molecular weight of ~33 kDa.
CD164 is a sialylamucin that may play a key role in the hematopoietic process, promoting CD34(+) cell adhesion while negatively regulating CD34(+)CD38(lo/-) cell proliferation. It regulates cord blood CD133+ cell migration through the CXCL12/CXCR4 axis and is associated with prostate cancer metastasis and bone marrow invasion. CD164 Protein, Human (HEK293, His) is the recombinant human-derived CD164 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD164 Protein, Human (HEK293, His) is 139 a.a., with molecular weight of 40-110 kDa.
CD164 Protein, a sialomucin, crucially influences hematopoiesis and cell adhesion. It enhances myogenesis by positively regulating myoblast migration and promoting the fusion of myoblasts into myotubes through interactions with CXCR4. This highlights CD164's significant role in various cellular activities related to muscle development and function. CD164 Protein, Rat (HEK293, Fc) is the recombinant rat-derived CD164 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD164 Protein, Rat (HEK293, Fc) is 160 a.a., with molecular weight of 90-120 kDa, respectively.
CD164 Protein, a sialomucin, potentially plays a pivotal role in hematopoiesis, facilitating CD34+ cell adhesion while negatively regulating CD34+ cell proliferation. CD164 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived CD164 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD164 Protein, Cynomolgus (HEK293, Fc) is 163 a.a., with molecular weight of 75-110 KDa.
B3GNT6 Protein, a vital beta-1,3-N-acetylglucosaminyltransferase, is crucial for synthesizing the core 3 structure of O-glycans, essential in mucin-type glycoprotein biosynthesis. With a key role in digestive organs, B3GNT6 significantly contributes to glycoconjugate structural diversity and functional properties. Its involvement in core 3 O-glycan synthesis is vital for mucin formation, impacting cell adhesion and mucosal protection processes. Understanding B3GNT6's role enhances glycosylation pathway comprehension, with potential applications in digestive organ physiology and glycan-related therapeutic targets. Further investigation promises insights into mucin-type glycoprotein biosynthesis in health and disease. B3GNT6 Protein, Human (sf9, His) is the recombinant human-derived B3GNT6 protein, expressed by Sf9 insect cells, with N-His labeled tag. The total length of B3GNT6 Protein, Human (sf9, His) is 341 a.a., with molecular weight of ~47 kDa.
HE4/WFDC2 protein is a disulfide-bonded homotrimer serving as a broad range protease inhibitor. HE4/WFDC2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived HE4/WFDC2 protein, expressed by HEK293, with C-His labeled tag. The total length of HE4/WFDC2 Protein, Mouse (HEK293, His) is 149 a.a., with molecular weight of ~23-30 kDa.
HE4/WFDC2 protein acts as a broad-spectrum protease inhibitor and may affect a variety of cellular processes. Its effect on sperm maturation suggests its role in reproductive mechanisms. HE4/WFDC2 Protein, Canine (HEK293, Fc) is the recombinant canine-derived HE4/WFDC2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of HE4/WFDC2 Protein, Canine (HEK293, Fc) is 97 a.a., with molecular weight of ~43-50 kDa.
CBFB, forming the heterodimeric complex core-binding factor (CBF) with RUNX family proteins, enhances the DNA-binding capacity of RUNX members like RUNX1, RUNX2, and RUNX3. The heterodimers bind to specific sites in enhancers and promoters, modulating transcription of target genes. CBFB complexes repress ZBTB7B during CD8+ T cell development, acting as a transcriptional silencer and facilitating cytotoxic T cell differentiation. Interactions occur with COPRS and PRMT5 in complexes with RUNX1. CBFB Protein, Human (His) is the recombinant human-derived CBFB protein, expressed by E. coli , with N-6*His labeled tag. The total length of CBFB Protein, Human (His) is 181 a.a., with molecular weight of ~25 kDa.
The HNRNPA1 protein is complexly involved in multiple RNA processing functions, packaging pre-mRNA into hnRNP particles, promoting Poly(A) mRNA transport, and regulating splice site selection. Crucially, it binds inhibitoryly to sequences flanking PKM exon 9, favoring the inclusion of exon 10 in pyruvate kinase PKM splicing, thereby generating the PKM M2 isoform. HNRNPA1 Protein, Human (His) is the recombinant human-derived HNRNPA1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of HNRNPA1 Protein, Human (His) is 353 a.a., with molecular weight of ~40.9 kDa.
Syndecan-2 Protein is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. Syndecan-2 functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Syndecan-2 is necessary for tumor angiogenesis that facilitates tumor growth and metastasis. Syndecan-2 Protein, Human (HEK293, His) is the recombinant human-derived Syndecan-2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Syndecan-2 Protein, Human (HEK293, His) is 126 a.a., with molecular weight of 25-40 kDa.
Studies have proven that Syndecan-4 protein is a cell surface proteoglycan that cooperates with SDCBP and PDCD6IP to play a key role in regulating exosome biogenesis. Syndecan-4 functions as a homodimer and interacts with various intracellular partners through its cytoplasmic domain. Syndecan-4 Protein, Human (HEK293, His) is the recombinant human-derived Syndecan-4 protein, expressed by HEK293 , with C-His labeled tag. The total length of Syndecan-4 Protein, Human (HEK293, His) is 145 a.a., with molecular weight of ~15.3 kDa.
The HE4/WFDC2 protein is a homotrimeric broad-spectrum protease inhibitor that regulates food intake, energy expenditure, and body weight in response to metabolic and toxin-induced stress. As a brainstem-restricted receptor, it binds to GDF15 and interacts with RET, activating MAPK and AKT signaling pathways. HE4/WFDC2 Protein, Human (HEK293, His) is the recombinant human-derived HE4/WFDC2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of HE4/WFDC2 Protein, Human (HEK293, His) is 94 a.a., with molecular weight of 18-22 kDa.
KLF6 Protein, a transcriptional activator, binds GC box motifs and may contribute to B-cell growth and development. It interacts with ZZEF1. KLF6 Protein, Human is the recombinant human-derived KLF6 protein, expressed by E. coli , with tag free. The total length of KLF6 Protein, Human is 109 a.a., with molecular weight of ~16.0 kDa.
Elafin/Trappin-2, a skin-specific inhibitor of neutrophil and pancreatic elastase, safeguards tissues against elastase-mediated proteolysis. Its inhibitory range extends to the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor. Elafin/Trappin-2 also weakly inhibits Kv11.1/KCNH2/ERG1 and transient receptor potential cation channel subfamily V member 1 (TRPV1), as reported in studies. Elafin/Trappin-2 Protein, Human (HEK293, His) is the recombinant human-derived Elafin/Trappin-2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Elafin/Trappin-2 Protein, Human (HEK293, His) is 95 a.a., with molecular weight of 13-15 kDa.
HBcAg Antibody (YA910) is an unconjugated, mouse-derived, anti-HBcAg (YA910) monoclonal antibody. HBcAg Antibody (YA910) can be used for: IHC-P expriments in human background without labeling.
ACAN Antibody is an unconjugated, approximately 208/248 kDa, rabbit-derived, anti-ACAN polyclonal antibody. ACAN Antibody can be used for: ELISA, IHC-P, IHC-F, IF expriments in mouse, rat, and predicted: human, chicken, dog, pig, cow, horse, rabbit background without labeling.
